Name: Mezcalería Santo Gusano
Address: Vasco de Quiroga 3800, Cuajimalpa, Mexico City, Mexico City, 05348
Telephone: +52 55 8854 4464
Price range: $$

About Mezcalería Santo Gusano

If you are exploring the dining scene in Mexico City and craving bold flavors from Oaxaca, Mezcalería Santo Gusano is the kind of place that instantly catches your attention. Tucked inside the Santa Fe area, this Oaxacan restaurant brings together traditional Mexican character with a relaxed and modern atmosphere that feels welcoming from the moment you arrive. The space has an energetic vibe, yet it still feels comfortable enough for a long meal with friends or a casual evening after work.

One thing that stands out at Mezcalería Santo Gusano is how strongly the restaurant embraces Oaxacan culture through its menu and drinks. The cocktail selection is especially popular, with mezcal-based creations that perfectly match the restaurant’s identity. If you enjoy trying different spirits, the variety of alcohol options, including beer, wine, and hard liquor, gives you plenty to explore. At the same time, the menu keeps things balanced with coffee and lighter bites for guests who prefer something more relaxed.

The food style leans heavily into authentic Oaxacan flavors without feeling overly formal. Small plates and quick bites make it easy to sample different dishes during one visit, which works great for groups sharing food around the table. The restaurant also offers dine-in and takeout service, making it convenient whether you want a full dining experience or simply want to enjoy the flavors at home. While delivery is not available, many guests still choose takeout because of the quality and freshness of the meals.

Another reason people keep returning to Mezcalería Santo Gusano is the atmosphere. The restaurant feels lively without becoming overwhelming, and the staff creates an easygoing environment that encourages guests to slow down, enjoy their drinks, and experience the richness of Oaxacan cuisine in a more personal way.

Special Menu

Tlayuda Con Extra de Tasajo

................................$

Guacamole Con Chapulines

................................$

Pulpo Zarandeado

................................$

Costillas Con Verdolagas

................................$

Flan de Cajeta

................................$

Enchiladas Cerdo En Mole

................................$

Mezcal de la Casa

................................$

Chile En Nogada

................................$

Full Menu

Gallery

Business Info

Service options

+ Takeout

+ Dine-in

+ No Delivery

Highlights

+ Great beer selection

+ Great cocktails

+ Great coffee

+ Great dessert

+ Rooftop seating

+ Sports

Popular for

+ Dinner

+ Solo dining

Accessibility

+ Wheelchair accessible entrance

+ Wheelchair accessible parking lot

+ Wheelchair accessible restroom

+ Wheelchair accessible seating

Offerings

+ Alcohol

+ Beer

+ Cocktails

+ Coffee

+ Hard liquor

+ Quick bite

+ Small plates

+ Wine

Dining options

+ Breakfast

+ Lunch

+ Dinner

+ Dessert

+ Seating

+ Table service

Amenities

+ Bar onsite

+ Restroom

+ Wi-Fi

Atmosphere

+ Casual

+ Cozy

+ Quiet

+ Trendy

Crowd

+ Groups

+ LGBTQ+ friendly

+ Tourists

+ Transgender safespace

Planning

+ Accepts reservations

Payments

+ Credit cards

+ Debit cards

+ NFC mobile payments

Children

+ Good for kids

+ Has changing table(s)

+ High chairs

+ Kids' menu

Parking

+ Paid parking lot

+ Parking

Hour time open

Right Now :

Monday: 09:00 AM - 11:00 PM
Tuesday: 09:00 AM - 11:00 PM
Wednesday: 09:00 AM - 11:00 PM
Thursday: 09:00 AM - 11:00 PM
Friday: 09:00 AM - 12:00 AM
Saturday: 09:00 AM - 12:00 AM
Sunday: 09:00 AM - 10:00 PM

Order Now

+52 55 8854 4464

Vasco de Quiroga 3800, Lomas de Santa Fe, Contadero, Cuajimalpa de Morelos, 05348 Ciudad de México, CDMX, Mexico

Reviews

Speechless. Food and service was beyond expectations. Rosaura was our waitress and she was professional and sweet. Absolutely recommend this place.

- Tomás Kavulakian -

Highly recommend this place! The food and cocktails are delicious. We got the Esquites, alcachofa, and tortitas de plátano as appetizers.

- Alejandra Gutierrez -

Excellent service! Guadalupe and Omar were wonderful, great recommendations. The Tlayuda Oaxaquena is a must! Also love the mezcal drinks and Haba soup. Will definitely come again.

- Gisela Ascencio -

Overall it was ok and I'll probably be back in some other visit to Mexico City. I enjoyed the black Mole with plantain On the other hand my hubby wasn't fully satisfied with his dish for the lack of balance on the amount of ingredients, too many undercooked beans because they were semi-hard, just a sprinkle of chorizo and just two over-easy eggs, the sauce was tasty. My friend had the omelette with huitlacoche (which is the mushroom/fungi that grows in the corn) and she said it lack some flavor The day we visited was pretty empty, and even though we appreciate the attentiveness of the staff being just there standing some steps away from our table, can make one feel a bit uncomfortable. Cafe de la Olla was good! Same with the orange juice and fresh fruit , both really fresh!

- A. M -

Amazing service amazing food. Will definitely be returning.

- karen manon -

lots of selections and staff are friendly and helpful. The food most importantly is superb

- Aaron Yang -

First time here and just loved it! Food was great, house mezcal was tasty and Miguel M. was amazing and took great care of us. Definitely will be back!

- Eric Colon -

Santo Gusano is a delightful experience of traditional cuisine. The food is not only tasty but crafted with great ingredients and rich storytelling. For a moment, I almost forgot I was in Mexico City, it felt like stepping into a traditional Oaxacan kitchen, where the flavors are truly unique and unforgettable.

- Tharyn Estévez -